Single nucleotide polymorphisms of TNF-Α gene in febrile seizures

Author(s): 
Zare-Shahabadi A1
Ashrafi MR2
Shahrokhi A3
Soltani S4
Zoghi S4
Soleimani F5
Vameghi R5
Badv RS2
Rezaei N6
Abstract: 

Febrile seizures (FS) is the most common seizure disorder during childhood. This study was performed in 78 patients with FS and 137 control subjects to assess polymorphisms of the TNF-α gene at positions -308 and -238, using the polymerase chain reaction and the sequence specific primers method. The highest positive allelic association that made the patients susceptible to FS was seen for TNF-α -238/G (p<0.0001). The GG genotype at TNF-α -238 was significantly higher in the patients with FS, compared to the controls (p=0.0001). Also, GA genotype at the same position was significantly lower in patients than in controls (P=0.0001). The GG haplotype had a significant positive association at TNF-α (308, 238) while GA haplotype showed a negative association (P<0.001). Our data support the idea that TNF-α single-nucleotide polymorphisms play a role in the pathogenesis of FS.

URL: 
https://www.ncbi.nlm.nih.gov/pubmed/26119396

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