Cancer Trends in Inborn Errors of Immunity: A Systematic Review and Meta-analysis

Prevalence of cancers is higher in IEI patients compared to immunocompetent individuals and cancers are considered as one of the most important and leading causes of death among IEI patients.

According to our findings, cancer rate among IEI patients is 40-fold higher compared to the global rate of cancer.

The highest number of reported IEI cases with cancer belonged to CVID, AT and Fanconi anemia, respectively.

Hematologic cancers followed by gastrointestinal cancers are the most prevalent cancers among these patients