Significance of IL-1RA Polymorphism in Iranian Patients with Inflammatory Bowel Disease

Author(s): 
Daryani NE1
Sadr M
Moossavi S
Shahkarami S
Soltani S
Farhadi E
Rezaei N
Abstract: 

BACKGROUND AND AIM:

Interleukin (IL)-1 family members play an important role in the pathogenesis of inflammatory bowel disease(IBD). There are conflicting results regarding the association of IL-1 gene cluster single nucleotide polymorphisms (SNPs) with IBD and its clinical features. The aim of this study was to examine IL-1α -889 C/T, IL-1β -511 C/T, IL-1β +3962 C/T, IL-1R Pst-I1970 C/T, and IL-1RA Mspa-I11100 C/T SNPs in Iranian patients.

METHODS:

In this study, SNPs of IL-1 family members were investigated in 75 patients with IBD (40 CD and 35 UC), using polymerase chain reaction with sequence-specific primers method.

RESULTS:

IL-1β -511 CC genotype was significantly less present in UC compared to controls, while IL-1RA Mspa-I11100 CC was significantly associated with both Crohn's disease (CD) and ulcerative colitis (UC). IL-1α -889 TT genotype was more frequently associated with extraintestinal manifestations. A significant association was observed between IL-1β +3962 TT genotype and thedisease activity in IBD. IL-1RA Mspa-I11100 CC was significantly less frequent in CD patients who need immunosuppressive therapy.IL-1RA Mspa-I11100 CT was associated with earlier age of onset in IBD, while TT genotype was associated with higher age of onset in IBD.

CONCLUSIONS:

IL-1 SNPs seem to be associated with IBD and could affect the disease severity as well.

URL: 
https://www.ncbi.nlm.nih.gov/pubmed/?term=Significance+of+IL-1RA+Polymorphism+in+Iranian+Patients+with+Inflammatory+Bowel+Disease

Contact Us

Research Center for Immunodeficiencies

Address: Pediatrics Center of Excellence, Children’s Medical Center Hospital, 62 Qarib St., Keshavarz Blvd., Tehran 14194, Iran

Research Center For immunodeficiency

Research Center For immunodeficiency