Total Antioxidant Status in Patients with Major β-Thalassemia
Borji Esfahani M
Beta-thalassemiamajor is an autosomal recessive disease causing severe and hemolytic anemia, which begins about 2-6 months after birth. Iron overload, which arises from recurrent transfusion and ineffective erythropoiesis, can enhance oxidative stress in thalassemicpatients. The aim of this study was to evaluate the serum totalantioxidant capacity of patients with ß-Thalassemiamajor.
Sixty six Iranian patients with β-thalassemiamajor and 66 age-gender matched controls were evaluated for serum totalantioxidantstatus (TAS), uric acid (UA), bilirubin and albumin. In addition, serum ferritin and transaminases were recorded in these subjects.
Significant increases of TAS, UA, and bilirubin were observed in the patient group, compared with the control group (P<0.01). Mean TAS and bilirubin in male patients was higher than in females (P=0.005 and P=0.008, respectively). There was also direct correlation between TAS and albumin (P<0.001), bilirubin (P<0.001) and UA (P=0.002).
Endogenous antioxidants such as ferritin, UA and bilirubin can result in increased level of TAS in the patients with Beta-thalassemiamajor. Compensatory excess of TAS to oxidative stress could also be the reason for difference between our findings and previous studies.
Research Center for Immunodeficiencies
Address: Pediatrics Center of Excellence, Children’s Medical Center Hospital, 62 Qarib St., Keshavarz Blvd., Tehran 14194, Iran